They will also attend multi-disciplinary meetings so their findings can be discussed with other clinicians. Histopathologists write reports on specimens, consult literature (past and current research findings), and many also have teaching and research responsibilities. For large specimens, such as samples of bowel or breast following surgery, these are dissected to select the most appropriate areas to examine under microscope. Many histopathologists specialise in specific organs such as the liver or skin, dissecting (‘cutting up’ or ‘trimming’) tissues for viewing under the microscope on a daily basis. (FISH) and polymerase chain reaction (PCR), to map the genetic material in tissues or tumours, which are essential in the management of many cancers.įind out what a histopathologist does, by hearing from Dr Mark Howard The role of the histopathologist With rapidly changing developments in molecular pathology, pathologists are leading the way with new techniques such as fluorescence in-situ hybridization. In certain limited circumstances using special techniques, the specimen can be examined immediately. Tissue is then processed, usually overnight, before being examined under a microscope. The peritoneum, the membrane lining the abdominal cavity). With the help of sophisticated imaging techniques, biopsy tissue can now be obtained from previously inaccessible sites such as the pancreas or retroperitoneum (behind Histopathologists provide a diagnostic service for cancer they handle the cells and tissues removed from suspicious ‘lumps and bumps’, identify the nature of the abnormality and, if malignant, provide information to the clinician about the type of cancer, its grade and, for some cancers, its responsiveness to certain treatments. Around 20 million histopathology slides are examined in the UK each year. They examine the tissue carefully under a microscope, looking for changes in cells that might explain what is causing a patient’s illness. They can reach a diagnosis by examining a small piece of tissue from the skin, liver, kidney or other organ. Histopathologists are doctors who work closely with other clinical specialties. Histopathologists are responsible for making tissue diagnoses and helping clinicians manage a patient’s care. Histopathology is the diagnosis and study of diseases of the tissues, and involves examining tissues and/or cells under a microscope.
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